Quick guide with the codes for each safe without gutting its contents.
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If you’re already making progress in Resident Evil Requiem, you’ll have noticed that several areas hide safes that can only be opened by entering the correct combination. Some hints are well-hidden and can be easily missed on the first playthrough.
To save you from having to scour every corridor repeatedly, we’ve got all the known combinations for you, organized by location. We won’t reveal what’s inside to avoid spoiling the surprises.
Safe Combinations in Resident Evil Requiem
Rhodes Hill Patient Center – West Wing (2nd floor)
- Combination: 10 left, 80 right, 30 left
Rhodes Hill Patient Center – East Wing (1st floor)
- Combination: 30 right, 10 left, 50 right
Rhodes Hill Patient Center – Basement
- Combination: 60 right, 40 left, 80 right
ARK – Sterilization Room
- Combination: 10 right, 90 left, 20 right
ARK – Control Room
- Combination: 50 right, 60 left, 80 right
Raccoon City Police Station – Briefcase
- Combination: R-R-R
Remember to enter the numbers in the exact correct order (left or right), as the system doesn’t allow for errors. If you’re aiming for 100% completion or just don’t want to leave anything behind, these combinations will save you a lot of time and work across all difficulty levels.

